朱华结，男，汉族，1964年5月出生，安徽省望江县人，理学博士，美国弗吉尼亚理工大学高级访问学者，“药物化学与分子诊断”教育部重点实验室副主任，“教育部创新团队”与河北省“巨人计划”骨干成员，中国科学院“国外杰出人才”，云南省自然科学科技进步三等奖，云南省自然科学二等奖，云南省政府特殊津贴，中国科学院王宽诚西部学者突出贡献奖获得者。
朱华结1987年本科毕业于武汉大学化学系，获理学学士学位，1990年毕业于武汉大学化学系，获理学硕士学位，1993年毕业于中国科学院昆明植物研究所，获理学博士学位。其后在美国密西西比州立大学学习工作，并获得Assistant Research Professor，先后担任美国MSU助理教授，第四届国际手性分子VOA大会组委会主席，第五届、六届国际VOA大会国际组委会中国区委员。现为河北大学药学院教授，博士研究生导师。
朱华结目前主要从事药用植物、微生物、有机化学与计算化学的多学科交叉的创新研究。
1987年，武汉大学化学系，获理学学士学位；
1990年，武汉大学化学系，获理学硕士学位。之后在云南省化工研究院工作，从事天然香料等半合成研究；
1993年，中国科学院昆明植物研究所，获理学博士学位。师承周俊院士，并拜师香港科技大学戴伟民教授及昆明植物所郝小江教授学习手性催化剂的设计与合成；
1998年，前往美国密西西比州立大学学习工作，并获得Assistant Research Professor；
2003年，获得中科院“国外杰出人才”；
2005年，到美国Virginia Tech （美国弗吉尼亚理工大学）做高级访问学者；
2011年至今，作为高层人才到河北大学工作。
围绕有机小分子的立体化学，尤其是天然产物的立体化学开展实验与理论相结合的多学科交叉创新研究。
《有机立体化学》、《天然产物化学》、《药物化学》。
1.主持：手性催化剂的构象对对映加成反应选择性的影响，国家基金委“主任专项”。
2.主持：八种藏药材资源调查与评价、化学成分分析，中国科学院重点项目
3.主持：天然产物化学中的应用计算化学研究，国家基金委基金
4.主持：手性f唑烷的设计、合成及其在中枢神经细胞保护中的活性研究，国家基金委基金
5.主持：中科院“国外杰出人才”基金。
6.主持：河北大学“高层引进人才”基金。
7.主要参与人：中国特有植物和微生物药用活性物质的基础研究，973项目中的子课题项目
8.主要参与人：教育部创新团队以及河北省“巨人计划”。
科研论文1. Li Liu, Qing Yang, He Yu, Jing-Liang Li, Yu-Ning Pei, Hua-Jie Zhu,*Zhen-Qiu Li, Xiao-Ke Wang, “Fitness of Driving Force and Catalytic Space in Chiral Catalyst Design. Application of Axial Biscarboline N-O Chiral Catalysts for Enantioselective Allylation of Allyltrichlorosilane to Bulky Substituted Aldehydes”Tetrahedron. 2015,71, 3296-3302.
2. H. Yu, W-X Li,J.-C. Wang,Q. Yang, H.-J. Wang,C.-C. Zhang, S.-S. Ding, Y. Li,H.-J Zhu,* “Pestalotiopsin C, Stereochemistry of A New Caryophyllene from a Fungus ofTrichodermasp. and Its Tautomerization Characteristics in Solution”,Tetrahedron. 2015,71, 3491-3494.
3. D.-B. Hu, W.-X. Li, Z.-Z. Zhao, T. Feng, R.H. Yin, Z.-H. Li, J.-K. Liu, H. J. Zhu*. “Highly unsaturated pyranone derivatives from the basidiomycete Junghuhnianitida”Tetrahedron Lett.2014,55, 6530-6533.
4. Jin-Liang Li, Li Liu, Yu-Ning Pei, Hua-Jie Zhu*, “Copper(II)-containing C2-symmetric bistetracarboline amides in enantioselective Henry reactions”.Tetrahedron, 2014,70, 9077-9083.
5. Yu-NingPei, Yu Deng, Jing-Liang Li, Hua-Jie Zhu“Chiral BiscarbolineN,N’-Dioxide Derivatives Catalyzed Asymmetric Reduction of Ketoimines with Trichlorosilane”Tetrahedron Lett,2014.55, 2948-2952.
6. Bing Bai,Xing-Yao Li, Li Liu,Yan Li,Hua-Jie Zhu*, “Syntheses of Novelβ-Carboline Derivatives and the Activities against Five Tumor-Cell Lines” .Bioorg. Med. Chem. Lett.2014,24, 96u201398.
7. Ping He, Xiangfen Wang, Xiujie Guo, Chuanqi Zhou, Shigang Shen, Dongbao Hu, Xiaolong Yang, Duqiang Luo, Rina Dukor, Huajie Zhu* “Vibrational Circular Dichroism Study for Natural Schizandrin fromPyrola rotundifoliaL. and Reassignment of Its Absolute Configuration”,Tetrahedron Lett.2014, 55, 2965u20132968.
8. Hua-Jie Zhu,* Wen-Xin Li, Dong-Bao Hu, Meng-Liang Wen, “Discussion of Absolute Configuration for Bioactive Griseusins by Comparing Computed Optical Rotations and Electronic Circular Dichroism with the Experimental Results”Tetrahedron, 2014,70, 8236-8243.
9. Wei Pan, Dongbao Hu, He Yu, Huajie Zhu*, “Mechanism Investigation of Hydrosilylation of Ketimines with Trichlorosilane Using Asymmetric-Axle-Supported ChiralN-OAmides and Absolute Configuration Discussion forN-Substituted Aniline” ,Tetrahedron2014,69, 7253-7257
10.S. Zhang, D.-B. Hu, J.-B. He, K.-Y. Guan, H.-J. Zhu,* “A NovelTetrahydroquinoline Acid and Two NewBenzofuranones fromCapparis spinosaL., A Case Study of Absolute Configuration Determination Using Quantum Methods” ,Tetrahedron2014,70, 869-873
11. Jiang-Bo He, Yan-Nan Ji, Dong-Bao Hu, Shen Zhang, Hui Yan, Xin-Chun Liu, Huai-Rong Luo, Hua-Jie Zhu* “Structure and AbsoluteConfigurationofPenicilliumine, a New Alkaloid fromPenicillium commune366606”,TetrahedronLett.2014.55, 2684-2686.
12. W. Pan, Y. Deng, J.-B. He, B. Bai, H.-J. Zhu*, “Highly Efficient Asymmetric-Axle-Supported N-O Amides in EnantioselectiveHydrosilylation of Ketimines with Trichlorosilane”,Tetrahedron, 2013,69, 7253-.
13. B.-X. Zhao, Y. Wang, C. Li, G.-C. Wang, X.-J. Huang, C.-L. Fan, Q.-M. Li, H.-J. Zhu*, W.-M. Chen*, W.-C. Ye*, “Flueggedine, a novel axisymmetric indolizidine alkaloid dimer from Flueggea virosa”,Tetrahedron Lett. 2013,54, 4708-4711.
14.Y. Deng,W. Pan,Y.-N.Pei, J.-L. Li, X.-C. Liu H.-J. Zhu*, “Asymmetric Addition of Aldehydes with Allytrichlorosianes Catalyzed by AxialN-O Secondary Amides”Tetrahedron2013.69.10431-10437.
15. Q.-M. Li, J. Ren, L. Shen, B. Bai Q.-M. Li, X.-C. Liu and M.-L. Wen, H.-J. Zhu*, “Determining the Absolute Configuration of Benzopyrenomycin from Optical Rotation, Electronic Circular Dichroism and Population Analysis of Different Conformations via DFT Methods”.Tetrahedron2013,69,3067-3074.
16. J. Ren, G-L Li, L Shen, G-L Zhang, Larance Nafie, H-J Zhu,* “Challenges in the Assignment of Relative and Absolute Configurations of Complex Molecules”Tetrahedron.2013,69,10351-10356.
17. B-D. Zhou, J. Ren, X.-C. Liuand H.-J. Zhu* “Theoretical and Experimental Study of the Absolute Configuration of Helical Structure of (2R,3S)-Rubiginone A2 Analog”Tetrahedron.2013,69, 1189-1194.
18. B. Bai, H.-J. Zhu,*W. Pan,“Structure Influence of Chiral 1,1u2032-Biscarboline-N,Nu2032-Dioxide on the Enantioselective Allylation of Aldehydes with Allyltrichlorosilanes”Tetrahedron.2012.68, 6829-6836.
19. B. Bai, L. Shen, J. Ren, H. J. Zhu* “Chiral BiscarbolineN,N’-Dioxide Derivatives. Highly Enantioselective Addition of Allyltrichlorosilane to Aldehydes”Advanced Synthesis and Catalysts,2012,354, 354-358.
20. Z.-G. Ding, J.-Y. Zhao, M.-G. Li, R. Huang, Q.-M. Li, X.-L. Cui, H.-J. Zhu,* and M.-L. Wen* “Griseusins F and G, Spiro-Naphthoquinones from a Tin Mine Tailings-Derived Alkalophilic Nocardiopsis Species”J. Nat. Prod.2012,75, 1994?1998.
21. S.-D. Zhao, L. Shen, D.-Q. Luo, H.-J. Zhu* “Progresses in Computational Methods Used in Natural Product Chemistry”Cur. Org. Chem.2011,15, 1843.
22. X.-N. Li,Y. Zhang,X.-H. Cai, T. Feng, Y.-P. Liu, Y. Li,J. Ren,H.-J. Zhuand X.-D. Luo“Psychotripine: a Novel Trimeric Pyrroloindoline Derivative from Psychotria pilifera”Org. Lett. 2011,13, 5896-5899.
23. B. Bai,X.-Y. Li, Y. Li,H.-J. Zhu* “Design, Synthesis andCytotoxic Activities ofNovelβ- Amino Alcohol DerivativesBioorg. Med. Chem. Lett.2011,21, 2302-2304.
24. Z.-G. Ding,M.-G. Li,J. Ren,J.-Y. Zhao,R. Huang,Q.-Z. Wang,X.-L. Cui,H.-J. Zhu*and M.-L. Wen* “Phenazinolins Au2013E: novel diphenazines from a tin mine tailings-derivedStreptomycesspecie”Org. & Biomol. Chem.2011,9, 2771.
25. F. Wang, Y.Gao, L. Zhang, B. Bai, Y. N. Hu, Z. J. Dong, Q. W. Zhai, H.- J. Zhu,* J. K Liu,.* “A Pair of Windmill-Shaped Enantiomers from Lindera aggregata with Activity toward Improvement of Insulin Sensitivity.”Org. Lett.2010,12, 3196-3199.
26. H-G. Ding, M.-G. Li, J.-Y. Zhao, J. Ren, R. Huang, M.-J. Xie, X.-L. Cui, H.-J. Zhu*, and M.-L. Wen* “Naphthospironone A, an Unprecedented Polycyclic Metabolite from an Alkaline Mine Waste Extremophile”.Chem.-A J. Eur. 2010,16, 3902 u2013 3905.
27. J. Ren,J.-X. Jiang, L.-B. Li,T.-G. Liao, R.-R. Tian, X.-L. Chen, S.-P. Jiang, C. U. Pittman, Jr. and H.-J. Zhu* “Assignment of Absolute Configuration ofConcentricolideand Absolute Configuration Determination of Its Bioactive Analogues Using DFT Methods.”Eur. J. Org. Chem. 2009. 3987-3991.
27. W. L. Xiao, C. Lei, J. Ren, T.-G. Liao, J.-X. Pu, C. U. Pittman, Y. Lu,Y.-T. Zheng, H.-J. Zhu*，H.-D. Sun* “Structure Elucidation and Theoretical Investigation of Key Steps in the Biogenetic Pathway of Schisanartane Nortriterpenoids Using DFT Methods”Chem.-A J. Eur.200814, 11584-11592.
28. L.-C. Li, J. Ren, J.-X. Jiang, H.-J. Zhu* “A Novel Direct Conversion of Primary Amides to the Corresponding Methyl Esters”Eur. J.Org. Chem. 2007, 1026-1030.
29. L. C. Li, J. X. Jiang, J. Ren, Y. Ren, C. U. Pittman, H. J. Zhu*, “Unexpected selectivity in sodium borohydride reductions of alpha-substituted esters: Experimental and theoretical studies”,Eur. J.Org. Chem.2006, 1981-1990.
30. J. Ren, L.-C. Li,J.-K. Liu, H. J. Zhu* C. U. Pittman, Jr., “Study of the Chemoselectivities of Primary, Secondary and Tertiary Amides in Sodium Borphydride Reactions”,Eur. J. Org. Chem.2006, 1991.
31. H. J. Zhu*, J. X. Jiang, S. Saobo, C. U. Pittman. “Chiral ligands Derived from Abrine 8. An Experimental and Theoretical Study of Free Ligand Conformational Preferences and the Addition of Diethylzinc to Benzaldehyde”J. Org. Chem.2005,70, 261-7.
32. H. J. Zhu, J. Ren, C. U. Pittman, Jr. “Matrix Model to Predict Specific Optical Rotations of Acyclic Chiral Molecules” Tetrahedron 2007, 63，2292-2314.
主要著作1. Hua-Jie Zhu, Organic Stereochemistry---Experimental and computational methods, Wiley-VCH，2015
2.朱华结 《现代有机立体化学》，科学出版社，2009.3。
发明专利1.朱华结;李良春，神经生长因子类似物（2S,4S）-2-（2u2019-取代基）-4-（吲哚-3-次甲基）-5,5-二取代基-1,3-f唑烷化合物，其制备方法及应用。专利号：ZL 2003 1 35767.9。
2.朱华结;李良春;蒋举兴;任洁，一种伯酰胺转化为相应甲酯的方法。专利号：ZL 2004 1 004018.7。
3.朱华结;吕晓,N-OR酰胺类化合物,其制备方法和其应用。专利号: 200710065964.4。
4.刘吉开;刘东泽;朱华结;王 飞;汤建国，韧革菌素及其制备方法和在药物上的应用，200610048625.0
5.朱华结;蒋举兴;任 洁，咔啉化合物,其应用和制备方法。专利号: ZL 200710066368.8。
6. 朱华结，李良波，任洁，二联噻吩类化合物，其药物组合物及应用。专利号：2009 1 0218293.X
7.朱华结;金 毅;徐树光;杨兆祥;普俊学，一种新的灯盏花乙素衍生物、其制备方法及其药物组合，200810097677.6
8.朱华结;金 毅;徐树光;杨兆祥;普俊学，4u2019,5,6-三甲氧基灯盏花乙素、其制备方法及其药物组合物，200810097680.8。
9. 美国专利，Oxazolidine derivatives as NMDA antagonists,申请号:. 61/021,608 (文件号: 026884-000200US（2008）)。PCT Int. Appl. 2009, 127pp. CODEN: PIXXD2 WO2009092324 A1 20090730.
10. 朱华结，白冰，1,1u2019-双咔啉N,Nu2019-二氧轴手性催化剂的合成及应用，ZL201110075166
11. 朱华结，白冰，李艳，β-咔啉衍生物或可药用盐，其制备方法及其抗肿瘤的应用，201310139090.8
12. 朱华结等，五味子素结构及其应用，201310492922.4
13. 有关立体化学数据处理软件著作权已获得登记，2015，第1073141号。
